Bisphosphonate-Associated Osteonecrosis of the Maxilla

The authors make a review of the current literature on the subject of bisphosphonateassociated osteonecrosis of the jaw bones. The modern theories about the occurrence of this complication resulting from bisphosphonate treatment of diseases characterized with high bone resorption are discussed. Modern understandings about the causes, risk factors and triggers for the occurrence of this disease are described. Attention is paid to the modern concepts of medication therapy and surgical treatment. A case of bisphosphonateassociated osteonecrosis of the maxilla with involvement of the maxillary sinus is reported. Surgical intervention comprising sequestrectomy, radical maxillary sinus surgery and plastic closure of the formed oroantral communication is described.